Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Urea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | F2 | P00734 | 3/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.59 |
| ▸ | SNCA | P37840 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetamide SCHEMBL9464850 | 0.93 | LMNA (0.56) | LMNAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL28275730 | 0.92 | SNCA (0.65) | LMNAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL29357423 | 0.92 | SNCA (0.65) | LMNAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL29857297 | 0.92 | SNCA (0.65) | LMNAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL1556 | 0.92 | SNCA (0.65) | LMNAF2PRSS1PRSS2PRSS3 | |
| Naphthalene SCHEMBL28216326 | 0.92 | SNCA (0.65) | LMNAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL304050 | 0.92 | SNCA (0.65) | LMNAF2PRSS1PRSS2PRSS3 | |
| Bicarbonate SCHEMBL7292653 | 0.90 | SNCA (0.64) | LMNAF2PRSS1PRSS2PRSS3 | |
| Methylamine SCHEMBL6339360 | 0.90 | LMNA (0.62) | LMNAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL9888352 | 0.90 | SNCA (0.62) | LMNAF2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591810-A | CURABLE MIXTURE OF POLYMERS IN SOLVENTS | HOECHST AKTIENGESSELSCHAFT (DE) | 1997-01-07 | — | — | US | disclosed |
| US-4804722-A | FURFURYL ALCOHOL-MODIFIED POLYEPOXIDE OR EPOXY RESIN BINDERS; ACID-CURED; FLEXIBILITY; CHEMICAL RESISTANCE | HOECHST AG (DE) | 1989-02-14 | — | — | US | disclosed |