Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382886 | 0.78 | NPSR1 (0.35) | NPSR1ALDH1A1SLC6A3HSD17B10ATM | |
| SCHEMBL883291 | 0.77 | — | — | |
| SCHEMBL17616387 | 0.69 | NPSR1 (0.40) | NPSR1ALDH1A1SLC6A3HSD17B10SMN1; SMN2 | |
| SCHEMBL882947 | 0.67 | NPSR1 (0.35) | NPSR1ALDH1A1 | |
| SCHEMBL14007321 | 0.67 | SMN1; SMN2 (0.36) | NPSR1ALDH1A1HSD17B10ATMKDM4C | |
| SCHEMBL17616386 | 0.64 | NPSR1 (0.40) | NPSR1ALDH1A1SLC6A3HSD17B10GAA | |
| SCHEMBL11368420 | 0.63 | NPSR1 (0.35) | NPSR1ALDH1A1 | |
| SCHEMBL8852201 | 0.63 | — | — | |
| SCHEMBL15586501 | 0.61 | SLC6A3 (0.46) | NPSR1SLC6A3HSD17B10SMN1; SMN2KCNH2 | |
| SCHEMBL15947267 | 0.60 | CHRM3 (0.35) | NPSR1ALDH1A1SLC6A3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040242-A1 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |