Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1419534 | 0.83 | GSK3A (0.45) | GSK3AGSK3BCYP3A4KMT2AMEN1 | |
| SCHEMBL15766434 | 0.79 | CYP1A2 (0.48) | CYP3A4KMT2AMEN1TSHRGAA | |
| SCHEMBL8581675 | 0.79 | CYP3A4 (0.55) | GSK3AGSK3BPGRCYP3A4KMT2A | |
| SCHEMBL22887339 | 0.79 | GSK3A (0.41) | GSK3AGSK3BCYP3A4KMT2AMEN1 | |
| SCHEMBL8830654 | 0.79 | MAPT (0.57) | GSK3AGSK3BPGRCYP3A4KMT2A | |
| SCHEMBL30284816 | 0.78 | ALDH1A1 (0.40) | GSK3AGSK3BKMT2AKDM4ETSHR | |
| SCHEMBL11443153 | 0.76 | KMT2A (0.53) | GSK3AGSK3BPGRKMT2AMEN1 | |
| SCHEMBL8830707 | 0.76 | KMT2A (0.53) | GSK3AGSK3BPGRKMT2AMEN1 | |
| SCHEMBL22421647 | 0.75 | KMT2A (0.51) | GSK3AGSK3BPGRCYP3A4KMT2A | |
| SCHEMBL5199351 | 0.74 | GSK3B (0.71) | GSK3AGSK3BPGRKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193878-B1 | 7,8-DIHYDRO-[2H]-IMIDAZO-[1,2-A]PYRAZOLO[4,3-E]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS PHOSPHODIESTERASE 1 (PDE1) INHIBITORS FOR TREATING DISEASES, DISORDERS OR INJURIES OF THE CENTRAL NERVOUS SYSTEM (CNS) | INTRA CELLULAR THERAPIES INC (US) | 2021-01-06 | — | — | EP | disclosed |
| EP-3725789-A1 | 7,8-DIHYDRO-[2H]-IMIDAZO-[1,2-A]PYRAZOLO[4,3-E]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS PHOSPHODIESTERASE 1 (PDE1) INHIBITORS FOR TREATING DISEASES, DISORDERS OR INJURIES OF THE CENTRAL NERVOUS SYSTEM (CNS) | Intra-Cellular Therapies, Inc. (US) | 2020-10-21 | — | — | EP | disclosed |
| US-5661153-A | FOR TREATING ALLERGIES, ASTHMA, DERMATITIS, GRAFT REJECTIONS | JAPAN ENERGY CORPORATION (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0700908-A1 | 1-Arylpyrimidine derivatives and pharmaceutical use thereof | JAPAN ENERGY CORPORATION (JP) | 1996-03-13 | — | — | EP | disclosed |