Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8830680 | 1.00 | KMT2A (0.59) | KMT2AMEN1GAAHPGDMAPT | |
| SCHEMBL22924167 | 0.81 | MAPT (0.57) | KMT2AMEN1GAAHPGDMAPT | |
| SCHEMBL24251256 | 0.75 | MAPT (0.60) | KMT2AMEN1HPGDMAPTALDH1A1 | |
| SCHEMBL1520549 | 0.73 | NTRK1 (0.69) | KMT2AMEN1HPGDMAPTALDH1A1 | |
| SCHEMBL19820158 | 0.72 | MAPT (0.57) | KMT2AMEN1HPGDMAPTALDH1A1 | |
| SCHEMBL12642190 | 0.72 | KMT2A (0.55) | KMT2AMEN1GAAHPGDMAPT | |
| SCHEMBL13573496 | 0.72 | CRHBP (0.60) | KMT2AMEN1GAAHPGDMAPT | |
| SCHEMBL5995561 | 0.72 | KMT2A (0.57) | KMT2AMEN1HPGDMAPTALDH1A1 | |
| SCHEMBL30665394 | 0.72 | NTRK1 (0.63) | KMT2AMEN1HPGDMAPTALDH1A1 | |
| SCHEMBL1519871 | 0.71 | NTRK1 (0.66) | KMT2AMEN1HPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627207-A | CANCER | FARMITALIA CARLO ERBA S R L (IT) | 1997-05-06 | — | — | US | disclosed |
| US-5488057-A | ENZYME INHIBITORS AND ANTICARCINOGENIC AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-01-30 | — | — | US | disclosed |
| EP-0662473-A1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA S.p.A. (IT) | 1995-07-12 | — | — | EP | disclosed |
| US-5374652-A | Substituted naphthylmethylene- or tetrahydronaphthylmethylene-derivatives of 2-oxoindole | FARMITALIA CARLO ERBA S R L (IT) | 1994-12-20 | — | — | US | disclosed |
| WO-1991013055-A2 | NEW ARYL- AND HETEROARYLETHENYLENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-09-05 | — | — | WO | disclosed |