Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702044 | 0.81 | ALOX15 (0.59) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8492523 | 0.80 | ALOX15 (0.57) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8493361 | 0.80 | ALOX15 (0.57) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8492285 | 0.80 | ALOX15 (0.57) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL11279591 | 0.80 | ALOX15 (0.57) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL646924 | 0.78 | ALOX15 (0.63) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8834596 | 0.77 | MAPT (0.53) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8699143 | 0.77 | HPN (0.53) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8530578 | 0.76 | ALOX15 (0.49) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8834359 | 0.75 | MAPT (0.52) | HPNMAPTALOX15SIRT5TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5635514-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | G. D. SEARLE & COMPANY (US) | 1997-06-03 | — | — | US | disclosed |
| WO-1996012703-A1 | HETEROALKYL AND HETEROARYLTHIOALKYL THIOPHENOLIC COMPOUNDS AS 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-05-02 | — | — | WO | disclosed |