Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 15/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623245 | 1.00 | OPRK1 (0.40) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8900202 | 1.00 | OPRK1 (0.40) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8901205 | 1.00 | OPRK1 (0.40) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL29878122 | 0.99 | OPRK1 (0.41) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL8900849 | 0.99 | OPRK1 (0.41) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8564463 | 0.99 | OPRK1 (0.41) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL8901918 | 0.99 | OPRK1 (0.41) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3405329 | 0.99 | OPRK1 (0.41) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8562982 | 0.95 | OPRK1 (0.39) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8558381 | 0.94 | OPRK1 (0.40) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679674-A | ANALGESICS | SANKYO COMPANY, LIMITED (JP) | 1997-10-21 | — | — | US | claimed |
| EP-0657443-A1 | OPTICALLY ACTIVE CARBOXAMIDE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1995-06-14 | — | — | EP | claimed |
| US-5679674-A | ANALGESICS | SANKYO COMPANY, LIMITED (JP) | 1997-10-21 | — | — | US | disclosed |
| EP-0657443-A1 | OPTICALLY ACTIVE CARBOXAMIDE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |