Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PTPRF | P10586 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HK2 | P52789 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5668728 | 0.87 | PTGS1 (0.41) | ALDH1A1MAPK1LPLLIPGPTGS2 | |
| Biphenyl SCHEMBL120429 | 0.68 | ALDH1A1 (0.75) | ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3 | |
| Biphenyl SCHEMBL598676 | 0.67 | ALDH1A1 (0.90) | ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3 | |
| Biphenyl SCHEMBL5087469 | 0.67 | ALDH1A1 (0.90) | ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3 | |
| Biphenyl SCHEMBL10610825 | 0.65 | ALDH1A1 (0.69) | ALDH1A1MAPK1LPLLIPGSLC22A2 | |
| Biphenyl SCHEMBL27656690 | 0.65 | ALDH1A1 (0.69) | ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3 | |
| Biphenyl SCHEMBL27660691 | 0.65 | ALDH1A1 (0.56) | ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3 | |
| Biphenyl SCHEMBL7411979 | 0.64 | ALDH1A1 (0.82) | ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3 | |
| Biphenyl SCHEMBL653702 | 0.64 | ALDH1A1 (0.82) | ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3 | |
| Biphenyl SCHEMBL7993413 | 0.64 | ALDH1A1 (0.82) | ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672626-A | ANTIINFLAMMATORY AGENT TREATING ARTHRITIS, PAIN, FEVER; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1997-09-30 | — | — | US | disclosed |
| US-5672627-A | ANTIINFLAMMATORY AGENT TREATING ARTHRITIS, PAIN, FEVER; ANTIPYRETICS | G.D. SEARLE & CO. (US) | 1997-09-30 | — | — | US | disclosed |
| US-5670510-A | SELECTIVELY INHIBIT CYCLOOXYGENASE II, ANTIARTHRITIC | G. D. SEARLE & CO. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |