Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735680 | 0.82 | HSD17B10 (0.65) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 | |
| SCHEMBL9223095 | 0.82 | ALDH1A1 (0.56) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 | |
| SCHEMBL30729659 | 0.80 | HSD17B10 (0.62) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 | |
| SCHEMBL7051985 | 0.80 | HSD17B10 (0.50) | HSD17B10KMT2AMEN1RXFP1KCNK3 | |
| SCHEMBL12812735 | 0.79 | HSD17B10 (0.61) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 | |
| SCHEMBL20152029 | 0.79 | HSD17B10 (0.61) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 | |
| SCHEMBL26464127 | 0.79 | HSD17B10 (0.61) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 | |
| SCHEMBL4820385 | 0.79 | HSD17B10 (0.61) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 | |
| SCHEMBL4003494 | 0.79 | HSD17B10 (0.61) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 | |
| SCHEMBL13255714 | 0.78 | HSD17B10 (0.59) | HSD17B10KMT2AMEN1RXFP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663181-A | Naphthyridine derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as antiproliferative drugs | LABORATOIRES UPSA (FR) | 1997-09-02 | — | — | US | disclosed |