Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540513 | 0.89 | MDM2 (0.48) | MDM2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL8541912 | 0.86 | MDM2 (0.45) | MDM2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL8541135 | 0.85 | MDM2 (0.43) | MDM2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8538967 | 0.84 | MDM2 (0.44) | MDM2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8540675 | 0.84 | MDM2 (0.46) | MDM2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL8541127 | 0.83 | MDM2 (0.44) | MDM2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL8546220 | 0.83 | MDM2 (0.43) | MDM2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL8541910 | 0.82 | MDM2 (0.43) | MDM2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8545284 | 0.81 | MDM2 (0.43) | MDM2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8836007 | 0.81 | MDM2 (0.43) | MDM2MEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |