Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8836109 | 0.88 | MAPK14 (0.43) | MAPK14RIPK2LCKKDRTGFBR1 | |
| SCHEMBL8836433 | 0.85 | MAPK14 (0.60) | MAPK14KDRMAPK11CSNK1DADORA2A | |
| SCHEMBL8836684 | 0.85 | MAPK14 (0.60) | MAPK14KDRMAPK11CSNK1DADORA2A | |
| SCHEMBL7491995 | 0.85 | MAPK14 (0.39) | MAPK14THRBMAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL8836232 | 0.84 | MAPK14 (0.59) | MAPK14KDRMAPK11CSNK1DADORA2A | |
| Hydrochloric Acid SCHEMBL8836091 | 0.84 | MAPK14 (0.59) | MAPK14KDRMAPK11CSNK1DADORA2A | |
| SCHEMBL16008438 | 0.82 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL20376949 | 0.80 | RIPK3 (0.48) | MAPK14RIPK3CSNK1DADORA2A | |
| SCHEMBL8836389 | 0.80 | THRB (0.59) | MAPK14TGFBR1THRBMAPK13MAPK12 | |
| SCHEMBL8836722 | 0.79 | MAPK14 (0.47) | MAPK14RIPK2LCKKDRTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624931-A | Pyrazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| US-5478827-A | Inhibits Interleukin-1 and tumor necrosis factor production | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5356897-A | Inhibit the production of Interleukin-1 and tumor necrosis factor; administering for treatment of chronic inflammatory diseases, autoimmune diseases and sepsis-induced organ injury | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| EP-0531901-A2 | Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |