S-Adenosylhomocysteine

S-Adenosylhomocysteine

SCHEMBL8836

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DOT1L Q8TEK3 9/20 1.00
▸ DNMT1 P26358 7/20 1.00
▸ DNMT3B Q9UBC3 6/20 1.00
▸ EZH2 Q15910 4/20 1.00
▸ CARM1 Q86X55 2/20 1.00
▸ EHMT2 Q96KQ7 2/20 1.00
▸ PRMT1 Q99873 2/20 1.00
▸ NNMT P40261 2/20 1.00
▸ TRDMT1 O14717 1/20 1.00
▸ PRMT5 O14744 1/20 1.00
▸ SUV39H1 O43463 1/20 1.00
▸ PRMT3 O60678 1/20 1.00
▸ INMT O95050 1/20 1.00
▸ NSD2 O96028 1/20 1.00
▸ PNMT P11086 1/20 1.00
▸ HNMT P50135 1/20 1.00
▸ WDR5 P61964 1/20 1.00
▸ KMT2A Q03164 1/20 1.00
▸ SETDB1 Q15047 1/20 1.00
▸ RBBP5 Q15291 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
S-Adenosylhomocysteine SCHEMBL12378912 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL12436336 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL18296901 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL10871157 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL17087726 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL16087786 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL17316162 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL14411397 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL804238 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1
S-Adenosylhomocysteine SCHEMBL21160481 1.00 DOT1L (1.00) DOT1LDNMT1DNMT3BEZH2CARM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6505 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122080098-A S-adenosyl homocysteine analogue, S-adenosyl-L-methionine analogue and application thereof — 2026-05-26 — — CN claimed
CN-114113560-B Blood metabolism marker for estimating Glomerular Filtration Rate (GFR) and application thereof 彭洪泉 2026-05-15 — — CN claimed
US-20260077012-A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES EPITRACKER INC (US) 2026-03-19 — — US claimed
WO-2026044146-A1 METHOD TO DISTINGUISH ASPARTATE FROM ISOASPARTATE IN A PROTEIN WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2026-02-26 — — WO claimed
US-20260056205-A1 METHOD TO DISTINGUISH ASPARTATE FROM ISOASPARTATE IN A PROTEIN WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2026-02-26 — — US claimed
EP-4692363-A1 METHOD FOR PRODUCING METHYL COMPOUND Mitsubishi Chemical Corporation (JP) 2026-02-11 — — EP claimed
US-20260034086-A1 Pet Food Compositions Comprising Caprylic Acid And Docosahexaenoic Acid And/Or Eicosapetaenoic Acid For Use In Treating Struvite Urolithiasis HILL'S PET NUTRITION, INC. (US) 2026-02-05 — — US claimed
US-12474354-B2 Disease risk assessment apparatus, disease risk assessment method, computer readable medium, and food for dementia prevention KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2025-11-18 — — US claimed
US-20250340848-A1 METHODS FOR CHEMICAL REPROGRAMMING AND PLURIPOTENT STEM CELLS PEKING UNIVERSITY (CN) 2025-11-06 — — US claimed
US-20250339475-A1 HEPATOPROTECTIVE PROBIOTIC COMPOSITIONS UNIV TEXAS (US) 2025-11-06 — — US claimed
EP-0726322-A1 Homocysteine assay AXIS BIOCHEMICALS AS (NO) 1996-08-14 — — EP claimed
WO-1996020010-A1 COMBINATION FOR REDUCING ANTIMICROBIAL RESISTANCE USING A METHYLATION INHIBITOR IN COMBINATION WITH AN ANTIBIOTIC ORIDIGM CORPORATION (US) 1996-07-04 — — WO claimed
EP-0486118-B1 Method for detecting cobalamin and folic acid deficiency COMPETITIVE TECH INC (US) 1996-06-12 — — EP claimed
EP-0623174-A1 HOMOCYSTEINE ASSAY. COCKBAIN JULIAN R M (GB) 1994-11-09 — — EP claimed
WO-1993015220-A1 HOMOCYSTEINE ASSAY AXIS BIOCHEMICALS AS (NO) 1993-08-05 — — WO claimed
EP-0486118-A1 Method for detecting cobalamin and folic acid deficiency COMPETITIVE TECHNOLOGIES INC. (US) 1992-05-20 — — EP claimed
US-5008188-A Reacting adenosine with homocysteine in aqueous medium in prescence of cells. NIPPON ZEON CO., LTD. (JP) 1991-04-16 — — US claimed
US-4940658-A Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency UNIVERSITY PATENTS, INC. (US) 1990-07-10 — — US claimed
EP-0269352-A2 Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficiency UNIVERSITY PATENTS, INC. (US) 1988-06-01 — — EP claimed
US-4605625-A RACEMIZATION WITH PSEUDOMONAS NIPPON ZEON CO., LTD. (JP) 1986-08-12 — — US claimed
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