Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8836007 | 0.89 | MDM2 (0.43) | MDM2KDM4EHPGDCRHBPCRHR2 | |
| SCHEMBL8540513 | 0.87 | MDM2 (0.48) | MDM2KDM4EHPGDCRHBPCRHR2 | |
| SCHEMBL8538967 | 0.85 | MDM2 (0.44) | MDM2KDM4EHPGDCRHBPCRHR2 | |
| SCHEMBL8541910 | 0.84 | MDM2 (0.43) | MDM2KDM4EHPGDCRHBPCRHR2 | |
| SCHEMBL8836023 | 0.82 | MDM2 (0.44) | MDM2KDM4EHPGDCRHBPCRHR2 | |
| SCHEMBL8540675 | 0.81 | MDM2 (0.46) | MDM2KDM4EHPGDMAPTLMNA | |
| SCHEMBL8541107 | 0.81 | MDM2 (0.47) | MDM2CRHBPCRHR2MAPTLMNA | |
| SCHEMBL8541912 | 0.80 | MDM2 (0.45) | MDM2KDM4EHPGDCRHBPCRHR2 | |
| SCHEMBL8541135 | 0.80 | MDM2 (0.43) | MDM2KDM4EHPGDCRHBPCRHR2 | |
| SCHEMBL8540708 | 0.80 | MDM2 (0.42) | MDM2HPGDMAPTLMNAELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |