Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8836467 | 0.91 | TERT (0.45) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| SCHEMBL8836020 | 0.85 | SLC6A2 (0.46) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| Hydrochloric Acid SCHEMBL8835778 | 0.84 | SLC6A2 (0.44) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| SCHEMBL3978255 | 0.79 | SLC6A2 (0.50) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| Hydrochloric Acid SCHEMBL8709005 | 0.77 | SLC6A2 (0.49) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| SCHEMBL8836619 | 0.77 | SLC6A2 (0.46) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| SCHEMBL8836015 | 0.74 | SLC6A2 (0.46) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| SCHEMBL8836040 | 0.73 | SLC6A2 (0.51) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| SCHEMBL8836625 | 0.72 | SLC6A2 (0.44) | KDM4ESLC6A2MEN1KMT2AHDAC1 | |
| Hydrochloric Acid SCHEMBL8835776 | 0.72 | SLC6A2 (0.44) | KDM4ESLC6A2MEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646300-A | NEUROPROTECTIVE AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5591866-A | NEUROPROTECTIVE AGENTS | HOECHST MARION ROUSSEL INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5565579-A | NEUROPROTECTIVE AGENT | HOECHST MARION ROUSSEL INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0563916-B1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5319096-A | Neuroprotective agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0563916-A1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-06 | — | — | EP | disclosed |