Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | GCGR | P47871 | 7/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | MATK | P42679 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496200 | 0.79 | MAPK14 (0.58) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5256356 | 0.79 | TDO2 (0.54) | MAPK14GCGRRPS6KA3NPC1RAB9A | |
| SCHEMBL30518879 | 0.75 | MAPT (0.55) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL1167560 | 0.75 | BRD4 (0.46) | RAB9A | |
| SCHEMBL27765844 | 0.74 | NPC1 (0.47) | RPS6KA3NPC1RAB9A | |
| SCHEMBL12338656 | 0.72 | MEN1 (0.41) | RETGSK3AGSK3BCLK4RPS6KA3 | |
| SCHEMBL5775812 | 0.70 | CYP19A1 (0.34) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL1168500 | 0.70 | MEN1 (0.47) | MAPK14GCGRSLC22A12RPS6KA3NPC1 | |
| SCHEMBL1167381 | 0.70 | GAK (0.50) | NPC1 | |
| SCHEMBL1168501 | 0.69 | MEN1 (0.46) | SLC22A12NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624931-A | Pyrazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| US-5478827-A | Inhibits Interleukin-1 and tumor necrosis factor production | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| EP-0531901-A2 | Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |