Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 2/20 | 0.41 |
| ▸ | DHCR24 | Q15392 | 9/20 | 0.41 |
| ▸ | CDC25A | P30304 | 3/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLA1 | P09884 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.36 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9350364 | 1.00 | MEN1 (0.42) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL9164370 | 1.00 | MEN1 (0.42) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL10587792 | 1.00 | MEN1 (0.42) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL10424858 | 1.00 | MEN1 (0.42) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL10587788 | 1.00 | MEN1 (0.42) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL9769614 | 0.87 | HMGCR (0.46) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL9353906 | 0.87 | MEN1 (0.43) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL11412835 | 0.84 | MEN1 (0.42) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL11411951 | 0.84 | MEN1 (0.42) | MEN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL11411677 | 0.84 | MEN1 (0.42) | MEN1USP2ALDH1A1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327119-B1 | Improved process for synthesis of 5-alpha-cholest-8(14)-en-3 beta-ol-15-one and other 15-oxygenated sterols | UNIV RICE WILLIAM M (US) | 1994-09-14 | — | — | EP | claimed |
| US-4900477-A | Novel intermediates and an improved process for producing the compound (3β,5α)-3-hydroxycholest-8(14)-en-15-one | AMERICAN CYANAMID COMPANY (US) | 1990-02-13 | — | — | US | claimed |
| US-4897475-A | OXYGENATION OF 7-DEHYDROCHOLESTEROL | WILLIAM MARSH RICE UNIVERSITY (US) | 1990-01-30 | — | — | US | claimed |
| EP-0335106-A2 | Novel intermediates and an improved process for producing the compound (3 beta, 5 alpha)-3-hydroxycholest-8(14)-en-15-one | AMERICAN CYANAMID COMPANY (US) | 1989-10-04 | — | — | EP | claimed |
| EP-0327119-A2 | Improved process for synthesis of 5-alpha-cholest-8(14)-en-3 beta-ol-15-one and other 15-oxygenated sterols | WILLIAM MARSH RICE UNIVERSITY (US) | 1989-08-09 | — | — | EP | claimed |
| US-5688780-A | ANTICHOLESTEROL AGENTS, CHOLESTEROL BIOSYNTHESIS INHIBITION | SRI INTERNATIONAL (US) | 1997-11-18 | — | — | US | disclosed |
| US-5510340-A | OXYSTEROL ANALOGS | SRI INTERNATIONAL (US) | 1996-04-23 | — | — | US | disclosed |
| EP-0644891-A1 | ANTIHYPERCHOLESTEROLEMIC COMPOUNDS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025568-A2 | ANTIHYPERCHOLESTEROLEMIC COMPOUNDS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 1993-12-23 | — | — | WO | disclosed |
| US-4900477-A | Novel intermediates and an improved process for producing the compound (3β,5α)-3-hydroxycholest-8(14)-en-15-one | AMERICAN CYANAMID COMPANY (US) | 1990-02-13 | — | — | US | disclosed |
| US-4897475-A | OXYGENATION OF 7-DEHYDROCHOLESTEROL | WILLIAM MARSH RICE UNIVERSITY (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0335106-A2 | Novel intermediates and an improved process for producing the compound (3 beta, 5 alpha)-3-hydroxycholest-8(14)-en-15-one | AMERICAN CYANAMID COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |
| US-4202891-A | ANOREXIGENIC AGENTS, ANTICHOLESTEROL AGENTS, INHIBITORS OF CELL GROWTH | PARISH, EDWARD J. | 1980-05-13 | — | — | US | disclosed |