SCHEMBL8837784

SCHEMBL8837784

CN(C)/C=C/C(=O)c1cccc(OC(F)(F)F)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.64
MAPT P10636 7/20 0.61
HTT P42858 5/20 0.61
GAA P10253 3/20 0.61
HPGD P15428 3/20 0.57
RECQL P46063 2/20 0.54
MAOB P27338 2/20 0.53
RAB9A P51151 3/20 0.52
NPC1 O15118 1/20 0.52
POLB P06746 1/20 0.52
HSP90AA1 P07900 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
LMNA P02545 3/20 0.49
CYP1A2 P05177 2/20 0.48
CYP2C19 P33261 2/20 0.48
TDP1 Q9NUW8 1/20 0.47
ABCG2 Q9UNQ0 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
TAS1R3 Q7RTX0 1/20 0.44
TAS1R1 Q7RTX1 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8837785 1.00 ALDH1A1 (0.64) ALDH1A1MAPTHTTGAAHPGD
SCHEMBL14969374 0.84 MAPT (0.62) ALDH1A1MAPTHTTGAAHPGD
SCHEMBL1549280 0.82 ALDH1A1 (0.67) ALDH1A1MAPTHTTGAAHPGD
SCHEMBL2162778 0.82 MAPT (0.71) ALDH1A1MAPTHTTGAAHPGD
SCHEMBL2162785 0.82 MAPT (0.71) ALDH1A1MAPTHTTGAAHPGD
SCHEMBL14537314 0.82 MAPT (0.71) ALDH1A1MAPTHTTGAAHPGD
SCHEMBL31276346 0.82 MAPT (0.71) ALDH1A1MAPTHTTGAAHPGD
SCHEMBL5946453 0.80 MAPT (0.77) ALDH1A1MAPTHTTGAAHPGD
SCHEMBL1033016 0.79 MAOB (0.53) ALDH1A1MAOBTDP1ABCG2HDAC8
SCHEMBL5823575 0.79 MAPT (0.66) ALDH1A1MAPTHTTGAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5612340-A ANTITUMOR AGENTS CIBA-GEIGY CORPORATION (US) 1997-03-18 US disclosed
EP-0672035-A1 PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Novartis AG (CH) 1995-09-20 EP disclosed
WO-1995009847-A1 PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF CIBA-GEIGY AG (CH) 1995-04-13 WO disclosed