Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 12/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | DMPK | Q09013 | 1/20 | 0.36 |
| ▸ | MYLK | Q15746 | 1/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883894 | 0.93 | ROCK1 (0.44) | ROCK1ROCK2MAPK1ATG4BSGK1 | |
| SCHEMBL883924 | 0.92 | ROCK1 (0.43) | ROCK1ROCK2MAPK1ATG4BSGK1 | |
| SCHEMBL883939 | 0.91 | ROCK2 (0.49) | ROCK1ROCK2MAPK1ATG4BSGK1 | |
| SCHEMBL352836 | 0.87 | ROCK2 (0.51) | ROCK1ROCK2MAPK1ATG4BSGK1 | |
| SCHEMBL353270 | 0.78 | ROCK2 (0.45) | ROCK1ROCK2MAPK1ATG4BEPHX2 | |
| SCHEMBL354050 | 0.76 | ROCK1 (0.54) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL353419 | 0.76 | ROCK2 (0.49) | ROCK1ROCK2MAPK1ATG4BSGK1 | |
| SCHEMBL351562 | 0.76 | ROCK1 (0.55) | ROCK1ROCK2MAPK1ATG4BSGK1 | |
| SCHEMBL351601 | 0.75 | ROCK2 (0.53) | ROCK1ROCK2MAPK1ATG4BSGK1 | |
| SCHEMBL353010 | 0.75 | ROCK2 (0.53) | ROCK1ROCK2MAPK1ATG4BSGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | claimed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | disclosed |