Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | DMPK | Q09013 | 1/20 | 0.37 |
| ▸ | MYLK | Q15746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884020 | 0.88 | ROCK2 (0.49) | ROCK2ROCK1EPHX2ATG4BNR1H4 | |
| SCHEMBL4725688 | 0.85 | ROCK2 (0.56) | ROCK2ROCK1EPHX2ATG4BSGK1 | |
| SCHEMBL352838 | 0.84 | ROCK2 (0.54) | ROCK2ROCK1EPHX2ATG4BKMT2A | |
| SCHEMBL353616 | 0.84 | ROCK2 (0.53) | ROCK2ROCK1EPHX2ATG4BKMT2A | |
| SCHEMBL355491 | 0.83 | ROCK2 (0.55) | ROCK2ROCK1EPHX2ATG4BKMT2A | |
| SCHEMBL354366 | 0.79 | ROCK2 (0.51) | ROCK2ROCK1ATG4BKMT2ASGK1 | |
| SCHEMBL353532 | 0.78 | ROCK2 (0.54) | ROCK2ROCK1EPHX2ATG4BKMT2A | |
| SCHEMBL352121 | 0.78 | ROCK1 (0.60) | ROCK2ROCK1EPHX2ATG4BSGK1 | |
| SCHEMBL353614 | 0.77 | ROCK2 (0.49) | ROCK2ROCK1ATG4BKMT2APOLB | |
| SCHEMBL354724 | 0.77 | ROCK1 (0.51) | ROCK2ROCK1EPHX2ATG4BSGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | claimed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | disclosed |