Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.51 |
| ▸ | PPARA | Q07869 | 16/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8840366 | 1.00 | PPARG (0.51) | PPARGPPARAFFAR1KDM4EPPARD | |
| SCHEMBL7480829 | 0.95 | PPARG (0.50) | PPARGPPARAFFAR1KDM4E | |
| SCHEMBL7480833 | 0.95 | PPARG (0.50) | PPARGPPARAFFAR1KDM4E | |
| SCHEMBL7486435 | 0.91 | PPARG (0.53) | PPARGPPARAFFAR1KDM4E | |
| SCHEMBL7486432 | 0.91 | PPARG (0.53) | PPARGPPARAFFAR1KDM4E | |
| SCHEMBL7164855 | 0.82 | PPARG (0.62) | PPARGPPARAPPARD | |
| SCHEMBL8795234 | 0.82 | FFAR1 (0.62) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL7489773 | 0.82 | PPARG (0.53) | PPARGPPARA | |
| SCHEMBL7485799 | 0.82 | PPARG (0.53) | PPARGPPARA | |
| SCHEMBL8840370 | 0.81 | PPARG (0.51) | PPARGPPARAFFAR1KDM4EPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614544-A | HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0643050-A1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | disclosed |