Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.53 |
| ▸ | PPARA | Q07869 | 13/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486432 | 1.00 | PPARG (0.53) | PPARGPPARAKDM4ECYP2C9CYP3A4 | |
| SCHEMBL8840366 | 0.91 | PPARG (0.51) | PPARGPPARAKDM4EFFAR1 | |
| SCHEMBL8840367 | 0.91 | PPARG (0.51) | PPARGPPARAKDM4EFFAR1 | |
| SCHEMBL7480829 | 0.89 | PPARG (0.50) | PPARGPPARAKDM4EFFAR1 | |
| SCHEMBL7480833 | 0.89 | PPARG (0.50) | PPARGPPARAKDM4EFFAR1 | |
| SCHEMBL7489094 | 0.83 | PPARG (0.53) | PPARGPPARAKDM4ECYP2C9CYP3A4 | |
| SCHEMBL9721160 | 0.82 | PPARG (0.54) | PPARGPPARAKDM4ECYP2C9CYP3A4 | |
| SCHEMBL9721163 | 0.82 | PPARG (0.54) | PPARGPPARAKDM4ECYP2C9CYP3A4 | |
| SCHEMBL7909689 | 0.81 | PPARG (0.63) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL9316940 | 0.79 | PPARG (0.44) | PPARGPPARACYP2C9CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643050-B1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-04-10 | — | — | EP | claimed |
| US-5614544-A | HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-25 | — | — | US | claimed |
| EP-0643050-A1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | claimed |
| US-5614544-A | HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0643050-A1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | disclosed |