Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.35 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 2/20 | 0.35 |
| ▸ | POLR1A | O95602 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8837019 | 0.90 | TACR3 (0.36) | POLR1AGAARAB9ASMN1; SMN2KMT2A | |
| SCHEMBL8842974 | 0.89 | CYP26A1 (0.46) | KMT2A | |
| SCHEMBL7329795 | 0.83 | TACR3 (0.48) | NPC1KMT2AMEN1 | |
| SCHEMBL7564581 | 0.83 | TACR3 (0.48) | NPC1KMT2AMEN1 | |
| SCHEMBL7333801 | 0.75 | GAA (0.39) | GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7325460 | 0.72 | PTPRC (0.38) | EGLN1PYGLGAAKMT2AMEN1 | |
| SCHEMBL9829253 | 0.68 | PLK1 (0.55) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL1114971 | 0.67 | TTR (0.40) | EGLN2EGLN1KMT2AMEN1 | |
| SCHEMBL18799916 | 0.66 | HTT (0.41) | RAB9ANPC1ALDH1A1 | |
| SCHEMBL1114965 | 0.66 | KDM4E (0.62) | GAARAB9ASMN1; SMN2NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663166-A | ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING | GENENTECH, INC. (US) | 1997-09-02 | — | — | US | disclosed |