Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3074753 | 0.80 | PHGDH (0.44) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL1872603 | 0.79 | PHGDH (0.48) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL17710560 | 0.79 | PHGDH (0.48) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL17710466 | 0.79 | PHGDH (0.48) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL17710528 | 0.79 | PHGDH (0.48) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL17710504 | 0.79 | PHGDH (0.48) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL17710535 | 0.79 | PHGDH (0.48) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL17710517 | 0.79 | PHGDH (0.48) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL3910736 | 0.77 | NOS2 (0.43) | PHGDHNOS2HSD11B1ALDH1A1 | |
| SCHEMBL3912450 | 0.77 | PHGDH (0.44) | PHGDHNOS2HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686495-A | Substituted hydrazinedicarboximidamides and methods of use thereof | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-11-11 | — | — | US | claimed |
| US-5686495-A | Substituted hydrazinedicarboximidamides and methods of use thereof | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5614630-A | NEUROTRANSMITTER RELEASE MODULATOR | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-03-25 | — | — | US | disclosed |