Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.30 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.30 |
| ▸ | MDH2 | P40926 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842967 | 0.91 | MEN1 (0.33) | PTGDR2CHRM5HDAC3HDAC4HDAC1 | |
| SCHEMBL7331333 | 0.90 | PTGDR2 (0.35) | PTGDR2ITGB3ITGA2BCHRM5HDAC3 | |
| SCHEMBL8842957 | 0.89 | ITGB3 (0.34) | ITGB3ITGA2B | |
| SCHEMBL7334770 | 0.86 | PTGDR2 (0.34) | PTGDR2ITGB3ITGA2BCHRM5HDAC3 | |
| SCHEMBL7330483 | 0.83 | ITGB3 (0.36) | PTGDR2ITGB3ITGA2B | |
| SCHEMBL7331728 | 0.82 | HDAC3 (0.37) | PTGDR2ITGB3ITGA2BHDAC3HDAC4 | |
| SCHEMBL7330721 | 0.82 | ITGB3 (0.36) | PTGDR2ITGB3ITGA2B | |
| SCHEMBL7321630 | 0.82 | ITGB3 (0.41) | PTGDR2ITGB3ITGA2BHDAC1HDAC6 | |
| SCHEMBL7335036 | 0.82 | ITGB3 (0.45) | PTGDR2ITGB3ITGA2BPRKAG1PRKAA1 | |
| SCHEMBL9009482 | 0.82 | PTGDR2 (0.34) | PTGDR2ITGB3ITGA2BCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663166-A | ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING | GENENTECH, INC. (US) | 1997-09-02 | — | — | US | disclosed |