Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | NPY2R | P49146 | 1/20 | 0.57 |
| ▸ | LIPE | Q05469 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8262692 | 0.95 | GAA (0.74) | GAANPC1RAB9ANPY2RLIPE | |
| SCHEMBL8844984 | 0.88 | GAA (0.68) | GAANPC1RAB9ANPY2RLIPE | |
| SCHEMBL2597837 | 0.88 | GAA (0.88) | GAANPC1RAB9ANPY2RLIPE | |
| SCHEMBL22081168 | 0.87 | GAA (0.63) | GAANPY2RLIPEHPGDPOLB | |
| SCHEMBL8844803 | 0.87 | GAA (0.67) | GAANPC1RAB9ALIPEHPGD | |
| SCHEMBL10458999 | 0.83 | GAA (0.74) | GAANPC1RAB9ANPY2RLIPE | |
| SCHEMBL8262856 | 0.82 | GAA (0.72) | GAANPC1RAB9ANPY2RLIPE | |
| SCHEMBL10458902 | 0.82 | GAA (0.72) | GAANPC1RAB9ALIPEHPGD | |
| SCHEMBL470967 | 0.81 | GAA (1.00) | GAANPC1RAB9ANPY2RLIPE | |
| SCHEMBL9542192 | 0.81 | GAA (0.75) | GAANPC1RAB9ANPY2RLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602151-A | ADMINISTERING TO MAMMALS TO REDUCE SERUM CHOLESTEROL LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-11 | — | — | US | claimed |
| US-5602151-A | ADMINISTERING TO MAMMALS TO REDUCE SERUM CHOLESTEROL LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| US-5512565-A | REDUCE CHOLESTEROL ABSORPTION IN MAMMALS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-30 | — | — | US | disclosed |
| US-5391571-A | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0428385-A1 | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-22 | — | — | EP | disclosed |