Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | LIPE | Q05469 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597837 | 0.92 | GAA (0.88) | GAANPC1RAB9ALIPEMEN1 | |
| SCHEMBL8844508 | 0.87 | NPC1 (0.69) | GAANPC1RAB9AMEN1KMT2A | |
| SCHEMBL470967 | 0.87 | GAA (1.00) | GAANPC1RAB9ALIPEMEN1 | |
| SCHEMBL9543461 | 0.86 | NPC1 (0.64) | GAANPC1RAB9AMEN1KMT2A | |
| SCHEMBL9544582 | 0.86 | NPC1 (0.64) | GAANPC1RAB9AMEN1KMT2A | |
| SCHEMBL9542252 | 0.85 | NPC1 (0.69) | GAANPC1RAB9AMEN1KMT2A | |
| SCHEMBL9542231 | 0.84 | NPC1 (0.64) | GAANPC1RAB9AMEN1KMT2A | |
| SCHEMBL9231431 | 0.83 | NPC1 (0.60) | GAANPC1RAB9AMEN1KMT2A | |
| SCHEMBL9542280 | 0.82 | NPC1 (0.62) | GAANPC1RAB9AMEN1KMT2A | |
| SCHEMBL8844984 | 0.81 | GAA (0.68) | GAANPC1RAB9ALIPELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013067-A1 | 4-SUBSTITUTED PIPERIDINECARBOXYLIC ACID ESTERS: INHIBITION OF CHOLESTEROL ABSORPTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-07-08 | — | — | WO | claimed |
| US-5169844-A | Enzyme inhibitor, anticholesterol and antilipemic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-08 | — | — | US | claimed |