Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | LIPE | Q05469 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8844965 | 0.86 | NPC1 (0.72) | NPC1RAB9AGAALIPEHSD17B10 | |
| SCHEMBL8845027 | 0.85 | NPC1 (0.71) | NPC1RAB9AGAALIPEHSD17B10 | |
| SCHEMBL8844771 | 0.85 | NPC1 (0.71) | NPC1RAB9AGAALIPEHSD17B10 | |
| SCHEMBL8844794 | 0.83 | NPC1 (0.67) | NPC1RAB9AGAALIPE | |
| SCHEMBL8480175 | 0.82 | NPC1 (1.00) | NPC1RAB9AGAALIPEHSD17B10 | |
| SCHEMBL2597837 | 0.81 | GAA (0.88) | NPC1RAB9AGAALIPEHSD17B10 | |
| SCHEMBL8844766 | 0.81 | NPC1 (0.76) | NPC1RAB9AGAALIPEHSD17B10 | |
| SCHEMBL27793338 | 0.81 | GAA (0.64) | NPC1RAB9AGAAMGLL | |
| SCHEMBL1502158 | 0.80 | GAA (0.68) | NPC1RAB9AGAALIPEMGLL | |
| SCHEMBL8844754 | 0.80 | NPC1 (0.63) | NPC1RAB9AGAALIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602151-A | ADMINISTERING TO MAMMALS TO REDUCE SERUM CHOLESTEROL LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-11 | — | — | US | claimed |