Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NPY2R | P49146 | 5/20 | 0.50 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8844800 | 0.87 | NPC1 (0.56) | NPC1RAB9AGAANPY2RLIPE | |
| SCHEMBL8845027 | 0.86 | NPC1 (0.71) | NPC1RAB9AGAANPY2RLIPE | |
| SCHEMBL8844794 | 0.84 | NPC1 (0.67) | NPC1RAB9AGAANPY2RLIPE | |
| SCHEMBL8844965 | 0.82 | NPC1 (0.72) | NPC1RAB9AGAALIPE | |
| SCHEMBL8844771 | 0.81 | NPC1 (0.71) | NPC1RAB9AGAALIPE | |
| SCHEMBL10089213 | 0.81 | GAA (0.70) | NPC1RAB9AGAANPY2R | |
| Iodide SCHEMBL8844833 | 0.80 | NPC1 (0.69) | NPC1RAB9AGAALIPE | |
| Iodide SCHEMBL8844876 | 0.80 | NPC1 (0.62) | NPC1RAB9AGAANPY2RLIPE | |
| SCHEMBL9542280 | 0.80 | NPC1 (0.62) | NPC1RAB9AGAANPY2R | |
| SCHEMBL2597837 | 0.79 | GAA (0.88) | NPC1RAB9AGAANPY2RLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602151-A | ADMINISTERING TO MAMMALS TO REDUCE SERUM CHOLESTEROL LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-11 | — | — | US | claimed |
| US-5602151-A | ADMINISTERING TO MAMMALS TO REDUCE SERUM CHOLESTEROL LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| US-5512565-A | REDUCE CHOLESTEROL ABSORPTION IN MAMMALS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0428385-A1 | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-22 | — | — | EP | disclosed |