Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.60 |
| ▸ | DRD3 | P35462 | 12/20 | 0.60 |
| ▸ | DRD4 | P21917 | 5/20 | 0.60 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845611 | 0.89 | DRD3 (0.64) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL8844914 | 0.88 | DRD2 (0.57) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL7439800 | 0.86 | DRD3 (0.59) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL8845326 | 0.85 | DRD2 (0.58) | DRD2DRD3DRD4HTR1ACYP2D6 | |
| SCHEMBL8845164 | 0.83 | DRD3 (0.52) | DRD2DRD3DRD4HTR1AFYN | |
| SCHEMBL9585366 | 0.83 | DRD2 (0.85) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL8845139 | 0.82 | DRD2 (0.52) | DRD2DRD3DRD4CYP2D6 | |
| SCHEMBL8845373 | 0.80 | DRD3 (0.53) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL8845020 | 0.79 | HTR1D (0.49) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL8845112 | 0.78 | DRD3 (0.51) | DRD2DRD3DRD4HTR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665765-A | TREATMENT OF PARKINSON'S DISEASE, MEMORY DISORDERS, DISORDERS ASSOCIATED WITH DRUG ABUSE, DEPRESSION, AND PSYCHOTIC STATES | ADIR ET COMPAGNIE (FR) | 1997-09-09 | — | — | US | disclosed |