Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 18/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 18/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 18/20 | 1.00 |
| ▸ | GABRA5 | P31644 | 18/20 | 1.00 |
| ▸ | GABRA3 | P34903 | 18/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 16/20 | 1.00 |
| ▸ | GABRA6 | Q16445 | 11/20 | 1.00 |
| ▸ | GABRP | O00591 | 10/20 | 1.00 |
| ▸ | GABRD | O14764 | 10/20 | 1.00 |
| ▸ | GABRB1 | P18505 | 10/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 10/20 | 1.00 |
| ▸ | GABRA4 | P48169 | 10/20 | 1.00 |
| ▸ | GABRE | P78334 | 10/20 | 1.00 |
| ▸ | GABRG1 | Q8N1C3 | 10/20 | 1.00 |
| ▸ | GABRG3 | Q99928 | 10/20 | 1.00 |
| ▸ | GABRQ | Q9UN88 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10417845 | 0.93 | GABRA1 (0.88) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31623760 | 0.93 | GABRA1 (0.86) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10417464 | 0.93 | GABRA1 (0.86) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10709775 | 0.92 | GABRA1 (0.85) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10710396 | 0.92 | GABRA1 (0.84) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10415982 | 0.92 | GABRA1 (0.84) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31623782 | 0.91 | GABRA1 (0.83) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31623783 | 0.91 | GABRA1 (0.83) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31623739 | 0.90 | GABRA1 (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9839878 | 0.90 | GABRA1 (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054507-B1 | 3-SUBSTITUTED BETA-CARBOLINES, PROCESS FOR THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-02-17 | — | — | EP | claimed |
| US-4435403-A | TRANQUILIZERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | claimed |
| EP-0054507-A2 | 3-Substituted beta-carbolines, process for their production and compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-06-23 | — | — | EP | claimed |
| WO-2025128933-A1 | GABA-A RECEPTOR POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2025-06-19 | — | — | WO | disclosed |
| US-5700808-A | TREATING SLEEP DISTURBANCE, EPILEPSY | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-12-23 | — | — | US | disclosed |
| US-5543519-A | 3-aryl or 3-hetaryl-β-carbolines, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-08-06 | — | — | US | disclosed |
| EP-0520987-A1 | METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO-$g(b)-CARBOLINE DERIVATIVES | NEUREX CORPORATION (US) | 1993-01-07 | — | — | EP | disclosed |
| US-5169852-A | Anorexigenic agents | NEUREX CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0520987-A4 | METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO--g(b)-CARBOLINE DERIVATIVES. | NEUREX CORP (US) | 1992-05-13 | — | — | EP | disclosed |
| EP-0190987-B1 | PROCESS FOR THE PRODUCTION OF BETA-CARBOLINES BY DEHYDROGENATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-04-03 | — | — | EP | disclosed |
| US-4978669-A | ALTERING MACRONUTRIENT PREFERENCE | NEUREX CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |
| US-4894377-A | ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-16 | — | — | US | disclosed |
| US-4877792-A | ANXIOLYTIC AGENTS; ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-10-31 | — | — | US | disclosed |
| EP-0054507-B1 | 3-SUBSTITUTED BETA-CARBOLINES, PROCESS FOR THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-02-17 | — | — | EP | disclosed |
| US-4719210-A | 3-vinyl and 3-thyinyl-beta-carbolines, and their use as benzodiazepine receptor antagonists or agonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-01-12 | — | — | US | disclosed |
| US-4644062-A | WITH TERT-BUTYL HYPOCHLORITE AND TERTIARY AMINE | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0190987-A2 | Process for the production of beta-carbolines by dehydrogenation | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-08-13 | — | — | EP | disclosed |
| US-4596808-A | Nervous system disorders | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-06-24 | — | — | US | disclosed |
| US-4435403-A | TRANQUILIZERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | disclosed |
| EP-0054507-A2 | 3-Substituted beta-carbolines, process for their production and compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-06-23 | — | — | EP | disclosed |