Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 17/20 | 0.72 |
| ▸ | GABRG2 | P18507 | 17/20 | 0.72 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.72 |
| ▸ | GABRA5 | P31644 | 17/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 17/20 | 0.72 |
| ▸ | GABRA2 | P47869 | 15/20 | 0.72 |
| ▸ | GABRP | O00591 | 8/20 | 0.72 |
| ▸ | GABRD | O14764 | 8/20 | 0.72 |
| ▸ | GABRB1 | P18505 | 8/20 | 0.72 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.72 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.72 |
| ▸ | GABRE | P78334 | 8/20 | 0.72 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.72 |
| ▸ | GABRG1 | Q8N1C3 | 8/20 | 0.72 |
| ▸ | GABRG3 | Q99928 | 8/20 | 0.72 |
| ▸ | GABRQ | Q9UN88 | 8/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845416 | 0.91 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8845459 | 0.89 | GABRA1 (0.84) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10388630 | 0.88 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9535915 | 0.87 | GABRA1 (0.72) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9838294 | 0.87 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8845232 | 0.87 | GABRA1 (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9075144 | 0.85 | GABRA1 (0.61) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8845905 | 0.85 | GABRA1 (0.79) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9536286 | 0.85 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9534849 | 0.84 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5414002-A | Anxiolytic agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-09 | — | — | US | claimed |
| EP-0239667-B1 | 5-OR 6-SUBSTITUTED BETA-CARBOLINE-3-CARBOXYLIC-ACID ESTERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-05-02 | — | — | EP | claimed |
| US-5700808-A | TREATING SLEEP DISTURBANCE, EPILEPSY | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-12-23 | — | — | US | disclosed |
| US-5414002-A | Anxiolytic agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-09 | — | — | US | disclosed |