Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.55 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.55 |
| ▸ | AGT | P01019 | 2/20 | 0.43 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303800 | 0.94 | AGTR1 (0.56) | AGTR1AGTR2AGTABCC3ABCC4 | |
| SCHEMBL1308518 | 0.93 | AGTR1 (0.65) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| Water SCHEMBL2576557 | 0.92 | AGTR1 (0.64) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL27353029 | 0.92 | AGTR1 (0.52) | AGTR1AGTR2AGTABCC3ABCC4 | |
| SCHEMBL27365761 | 0.92 | AGTR1 (0.52) | AGTR1AGTR2AGTABCC3ABCC4 | |
| SCHEMBL7308711 | 0.91 | AGTR1 (0.59) | AGTR1AGTR2AGT | |
| SCHEMBL7886503 | 0.91 | AGTR1 (0.51) | AGTR1AGTR2AGTABCC3ABCC4 | |
| SCHEMBL7301890 | 0.86 | AGTR1 (0.51) | AGTR1AGTR2AGTABCC3ABCC4 | |
| Lithium Ion SCHEMBL3342418 | 0.85 | AGTR1 (0.60) | AGTR1AGTR2AGTABCC3ABCC4 | |
| Potassium Ion SCHEMBL1975309 | 0.85 | AGTR1 (0.60) | AGTR1AGTR2AGTABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1051766-C | Angiotensin II antagonist imidazole derivatives, their preparation and their theapeutic use | SANKYO CO (JP) | 2000-04-26 | — | — | CN | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |