Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27461735 | 0.84 | CNR2 (0.62) | MAPTCNR2PTPN5KIF11CNR1 | |
| SCHEMBL5735874 | 0.82 | RORC (0.47) | MAPTCNR2POLBERN1PTPN5 | |
| SCHEMBL5737735 | 0.80 | MAPT (0.58) | MAPTCNR2POLBERN1KIF11 | |
| SCHEMBL8845859 | 0.78 | AKR1C3 (0.47) | ERN1KDM4ESMN1; SMN2PTPN5ALDH1A1 | |
| SCHEMBL2935772 | 0.78 | CNR2 (0.52) | MAPTCNR2SMN1; SMN2PTPN5KIF11 | |
| SCHEMBL6267216 | 0.77 | TRIM24 (0.59) | ERN1LMNAKMT2ATDP1TRIM24 | |
| SCHEMBL18529813 | 0.76 | ERN1 (0.49) | ERN1TRIM24TRIM33P2RX1IKBKB | |
| SCHEMBL2478195 | 0.76 | RORC (0.50) | MAPTCNR2POLBKDM4EPTPN5 | |
| SCHEMBL13388270 | 0.75 | KCNA5 (0.48) | MAPTPOLBLMNATRIM24TRIM33 | |
| SCHEMBL1802275 | 0.75 | MAPT (0.46) | MAPTCNR2POLBKDM4EPTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |