Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 14/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885040 | 0.86 | KCNA5 (0.46) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884625 | 0.85 | KCNA5 (0.53) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884592 | 0.83 | KCNA5 (0.46) | KCNA5KCNH2SMN1; SMN2TSHR | |
| SCHEMBL884872 | 0.83 | KCNA5 (0.53) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL885079 | 0.80 | KCNA5 (0.56) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884575 | 0.79 | KCNA5 (0.52) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884331 | 0.79 | KCNA5 (0.49) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884862 | 0.78 | KCNA5 (0.57) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884337 | 0.77 | KCNA5 (0.60) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL2062493 | 0.75 | KCNA5 (0.50) | KCNA5KCNH2CFTRSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |