Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 16/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884632 | 0.86 | KCNA5 (0.49) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884819 | 0.85 | KCNA5 (0.53) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884584 | 0.83 | KCNA5 (0.49) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884563 | 0.82 | KCNA5 (0.51) | KCNA5KCNH2GRM5 | |
| SCHEMBL884975 | 0.82 | KCNA5 (0.52) | KCNA5KCNH2CFTRGOPC | |
| SCHEMBL884875 | 0.82 | KCNA5 (0.56) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL884464 | 0.81 | KCNA5 (0.56) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL2062493 | 0.80 | KCNA5 (0.50) | KCNA5KCNH2CFTRSLC6A2SLC6A4 | |
| SCHEMBL2062733 | 0.78 | KCNA5 (0.54) | KCNA5KCNH2 | |
| SCHEMBL885036 | 0.78 | KCNA5 (0.48) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |