SCHEMBL8846547

SCHEMBL8846547

c1ccc(P(CCP(c2ccccc2)c2cccc3ccccc23)c2cccc3ccccc23)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.40
CA12 O43570 1/20 0.39
CA3 P07451 1/20 0.39
CA4 P22748 1/20 0.39
CA6 P23280 1/20 0.39
CA5A P35218 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
CA5B Q9Y2D0 1/20 0.39
ALDH1A1 P00352 7/20 0.38
TSHR P16473 4/20 0.38
HSD17B10 Q99714 4/20 0.38
RECQL P46063 1/20 0.38
CYP2A6 P11509 3/20 0.37
CYP1A2 P05177 5/20 0.35
HPGD P15428 3/20 0.35
CYP3A4 P08684 2/20 0.35
KEAP1 Q14145 1/20 0.35
CYP2C19 P33261 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11125323 0.87 CYP1A2 (0.45) TDP1CA12CA3CA4CA6
SCHEMBL15658216 0.85 TLR8 (0.36) TDP1ALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL15659078 0.85 TDP1 (0.38) TDP1CA12CA3CA4CA6
SCHEMBL15658621 0.84 KCNH2 (0.38) TDP1ALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL15656855 0.84 KCNH2 (0.38) TDP1ALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL648243 0.83 TDP1 (0.37) TDP1CA12CA3CA4CA6
SCHEMBL10757313 0.80 TDP1 (0.35) TDP1CA12CA3CA4CA6
SCHEMBL8051835 0.79 CYP1A2 (0.42) TDP1CA12CA3CA4CA6
SCHEMBL11129209 0.79 CYP1A2 (0.42) TDP1CA12CA3CA4CA6
SCHEMBL8655772 0.79 CA12 (0.44) TDP1CA12CA3CA4CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648201-B1 ENANTIOSELECTIVE HYDROGENATION OF THE CARBONYL BOND USING RUTHENIUM COMPLEXES WITH BIPHOSPHINE LIGANDS ELF AQUITAINE (FR) 1997-01-22 EP disclosed
EP-0571515-B1 CHIRAL PHOSPHINITE-BORANES, THEIR PREPARATION AND USE ELF AQUITAINE (FR) 1995-11-29 EP disclosed
US-5434285-A WHICH ARE STRUCTURALLY DIFFERENT THAN THE PRIOR ART SOCIETE NATIONALE ELF AQUITAINE (FR) 1995-07-18 US disclosed
US-5426216-A Employing complex of ruthenium with diphosphine and allylic ligands SOCIETY NATIONALE ELF AQUITAINE (FR) 1995-06-20 US disclosed
EP-0648201-A1 Enantioselective hydrogenation of the carbonyl bond using ruthenium complexes with biphosphine ligands. ELF AQUITAINE (FR) 1995-04-19 EP disclosed
WO-1994001390-A1 ENANTIOSELECTIVE CARBONYL GROUP HYDROGENATION METHOD USING RUTHENIUM/DIPHOSPHINE LIGAND COMPLEXES ELF AQUITAINE (FR) 1994-01-20 WO disclosed
EP-0571515-A1 CHIRAL PHOSPHINITE-BORANES, THEIR PREPARATION AND USE. ELF AQUITAINE (FR) 1993-12-01 EP disclosed
US-5264602-A Chiral phosphinite-boranes, their preparation and uses SOCIETE NATIONALE ELF AQUITAINE (FR) 1993-11-23 US disclosed
WO-1992014739-A1 CHIRAL PHOSPHINITE-BORANES, THEIR PREPARATION AND USE SOCIETE NATIONALE ELF AQUITAINE (FR) 1992-09-03 WO disclosed