Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
| ▸ | GGT1 | P19440 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868867 | 0.89 | PTGS2 (0.53) | TYRHPGDKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL9979219 | 0.83 | TSHR (0.49) | HPGDKDM4EHSD17B10ALDH1A1PTGS1 | |
| SCHEMBL25272705 | 0.83 | ESR1 (0.40) | HPGDKDM4EHSD17B10ALDH1A1PTGS1 | |
| SCHEMBL10524187 | 0.80 | KDM4E (0.42) | HPGDKDM4EHSD17B10ALDH1A1PTGS1 | |
| SCHEMBL1790171 | 0.80 | KDM4E (0.42) | HPGDKDM4EHSD17B10ALDH1A1PTGS1 | |
| SCHEMBL29655932 | 0.80 | KDM4E (0.42) | HPGDKDM4EHSD17B10ALDH1A1PTGS1 | |
| SCHEMBL10541465 | 0.79 | TYR (0.46) | TYRHPGDKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL17386335 | 0.79 | TYR (0.40) | TYRHPGDKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL15899545 | 0.79 | HPGD (0.38) | HPGDKDM4EHSD17B10ALDH1A1PTGS1 | |
| SCHEMBL5941442 | 0.79 | IDO1 (0.56) | TYRHPGDALDH1A1PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643926-A | Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations thereof | ELI LILLY AND COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| US-5399565-A | Treatment of psychological, central nervous system and gastrointestinal disorders | ELI LILLY AND COMPANY (US) | 1995-03-21 | — | — | US | disclosed |
| US-5300514-A | Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations thereof | ELI LILLY AND COMPANY (US) | 1994-04-05 | — | — | US | disclosed |