Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 11/20 | 0.50 |
| ▸ | TUBB | P07437 | 11/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 11/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 11/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 11/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 11/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 11/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 11/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 11/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 11/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 11/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 11/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 11/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 11/20 | 0.50 |
| ▸ | TUBB1 | Q9H4B7 | 11/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062719 | 0.81 | KCNA5 (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL884975 | 0.80 | KCNA5 (0.52) | KDRKDM4EKCNA5KCNH2 | |
| SCHEMBL884875 | 0.80 | KCNA5 (0.56) | SMN1; SMN2KDM4EKCNA5KCNH2 | |
| SCHEMBL884797 | 0.80 | KCNA5 (0.46) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL884574 | 0.79 | KCNA5 (0.46) | NPC1MAPTKCNA5KCNH2 | |
| SCHEMBL886205 | 0.79 | KCNA5 (0.61) | NPC1RAB9AKCNA5KCNH2 | |
| SCHEMBL884464 | 0.79 | KCNA5 (0.56) | KDM4EKCNA5KCNH2 | |
| SCHEMBL885036 | 0.78 | KCNA5 (0.48) | KDM4EMAPTKCNA5KCNH2 | |
| SCHEMBL2062733 | 0.78 | KCNA5 (0.54) | KDRRAB9ASMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL1375914 | 0.78 | TUBB4A (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | claimed |
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | TUBB4A 2378/4885TUBB 1696/4885TUBA3C 1594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.