Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8848040 | 0.86 | HDAC1 (0.44) | SLC1A3SLC1A2SLC1A1TSHRCA2 | |
| SCHEMBL7426363 | 0.83 | SLC1A3 (0.40) | SLC1A3SLC1A2SLC1A1USP2TSHR | |
| SCHEMBL28149631 | 0.82 | SLC1A3 (0.39) | SLC1A3SLC1A2SLC1A1USP2TSHR | |
| SCHEMBL276583 | 0.79 | — | — | |
| SCHEMBL1716335 | 0.78 | SLC1A3 (0.58) | SLC1A3SLC1A2SLC1A1USP2TSHR | |
| SCHEMBL28398347 | 0.78 | TSHR (0.41) | SLC1A3SLC1A2SLC1A1USP2TSHR | |
| SCHEMBL20490062 | 0.78 | SLC1A3 (0.37) | SLC1A3SLC1A2SLC1A1USP2TSHR | |
| SCHEMBL8847892 | 0.78 | TSHR (0.30) | TSHR | |
| SCHEMBL8314295 | 0.78 | SLC1A3 (0.58) | SLC1A3SLC1A2SLC1A1USP2TSHR | |
| SCHEMBL9764128 | 0.72 | TSHR (0.33) | SLC1A3SLC1A2SLC1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |