Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11561306 | 0.79 | CA1 (0.34) | TSHR | |
| SCHEMBL153102 | 0.78 | — | — | |
| SCHEMBL8847601 | 0.78 | SLC1A3 (0.35) | TSHR | |
| SCHEMBL17953985 | 0.77 | PTPN1 (0.35) | TSHR | |
| SCHEMBL1782275 | 0.77 | PTPN1 (0.35) | TSHR | |
| SCHEMBL9550634 | 0.77 | NAALAD2 (0.46) | — | |
| SCHEMBL1572858 | 0.77 | NAALAD2 (0.46) | — | |
| SCHEMBL9272361 | 0.77 | NAALAD2 (0.46) | — | |
| SCHEMBL20490063 | 0.77 | TSHR (0.32) | TSHR | |
| SCHEMBL277544 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |