Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158112 | 0.88 | ACACB (0.45) | PRKCZEGLN1NPSR1HSP90AA1ESR2 | |
| SCHEMBL8847450 | 0.87 | PRKCZ (0.39) | PRKCZMMEGAAHTTACACB | |
| Hydrochloric Acid SCHEMBL4437775 | 0.86 | ACACB (0.44) | PRKCZEGLN1NPSR1HSP90AA1ESR2 | |
| SCHEMBL1144471 | 0.81 | HSP90AA1 (0.57) | EGLN1HSP90AA1ESR2TDP1MME | |
| SCHEMBL9413571 | 0.78 | PRKCZ (0.40) | PRKCZEGLN1TDP1MMEALDH1A1 | |
| SCHEMBL4363219 | 0.77 | GAA (0.43) | PRKCZTDP1ALDH1A1PARP4GAA | |
| SCHEMBL8847760 | 0.76 | ADORA1 (0.46) | NPSR1HSP90AA1ESR2TDP1APEX1 | |
| SCHEMBL3674991 | 0.76 | EGLN1 (0.41) | PRKCZEGLN1HSP90AA1ESR2TDP1 | |
| SCHEMBL28048356 | 0.75 | ACACB (0.44) | PRKCZEGLN1APEX1MMEALDH1A1 | |
| SCHEMBL8848140 | 0.75 | ACACB (0.44) | PRKCZAPEX1ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |