Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 13/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.32 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8848089 | 0.93 | TOP2A (0.46) | TOP2ATDP1CDC25BCSNK1A1CSNK1D | |
| SCHEMBL8847912 | 0.87 | TOP2A (0.46) | TOP2ACDC25B | |
| SCHEMBL7812061 | 0.86 | TOP2A (0.45) | TOP2ATDP1 | |
| SCHEMBL7817561 | 0.84 | TOP2A (0.41) | TOP2ACDC25B | |
| SCHEMBL7804662 | 0.84 | TOP2A (0.48) | TOP2ATDP1CDC25B | |
| SCHEMBL7814010 | 0.82 | TOP2A (0.45) | TOP2ACDC25B | |
| SCHEMBL7827886 | 0.82 | TOP2A (0.36) | TOP2ACDC25B | |
| SCHEMBL7804837 | 0.81 | TOP2A (0.50) | TOP2ACDC25B | |
| SCHEMBL7812072 | 0.80 | MAPK13 (0.44) | TOP2ACDC25B | |
| SCHEMBL10801104 | 0.79 | TOP2A (0.54) | TOP2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |
| US-5519029-A | ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1996-05-21 | — | — | US | disclosed |