Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.33 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847987 | 0.93 | TOP2A (0.45) | TOP2ACDC25BCSNK1A1CSNK1DCSNK1E | |
| SCHEMBL8847912 | 0.89 | TOP2A (0.46) | TOP2ACDC25BMAOAMAOBKDM4E | |
| SCHEMBL10801104 | 0.86 | TOP2A (0.54) | TOP2ATDP1 | |
| SCHEMBL7817561 | 0.86 | TOP2A (0.41) | TOP2ACDC25BMAOAMAOBECE1 | |
| SCHEMBL7804662 | 0.86 | TOP2A (0.48) | TOP2ACDC25BTDP1KDM4ETP53 | |
| SCHEMBL7812061 | 0.84 | TOP2A (0.45) | TOP2ATDP1 | |
| SCHEMBL7814010 | 0.84 | TOP2A (0.45) | TOP2ACDC25BSMN1; SMN2 | |
| SCHEMBL7827886 | 0.84 | TOP2A (0.36) | TOP2ACDC25BMAOAMAOBKDM4E | |
| SCHEMBL7804837 | 0.83 | TOP2A (0.50) | TOP2ACDC25BKDM4ETP53CYP3A4 | |
| SCHEMBL7820225 | 0.83 | ECE1 (0.49) | TOP2AMAOAMAOBECE1MUS81 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |
| US-5519029-A | ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1996-05-21 | — | — | US | disclosed |