Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965536 | 0.73 | HRH3 (0.46) | HRH3POLBLMNAMAPTKMT2A | |
| SCHEMBL11170870 | 0.71 | HRH3 (0.44) | HRH3POLBLMNAMAPTKMT2A | |
| SCHEMBL17552000 | 0.71 | HRH3 (0.48) | HRH3POLBLMNAMAPTKMT2A | |
| SCHEMBL967849 | 0.71 | HRH3 (0.48) | HRH3POLBLMNAMAPTKMT2A | |
| SCHEMBL12128803 | 0.69 | CHRM5 (0.47) | HRH3POLBMAPTKMT2A | |
| SCHEMBL989862 | 0.68 | — | — | |
| SCHEMBL25433068 | 0.67 | POLB (0.48) | HRH3POLBLMNAMAPTKMT2A | |
| SCHEMBL2840150 | 0.67 | — | — | |
| SCHEMBL7286457 | 0.67 | HRH3 (0.50) | HRH3POLBLMNAMAPTKMT2A | |
| SCHEMBL3770379 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637731-A | CHOLINERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-10 | — | — | US | disclosed |
| US-5550257-A | TREATING CENTRAL CHOLINERGIC DYSFUNCTION | AMERICAN CYANAMID COMPANY (US) | 1996-08-27 | — | — | US | disclosed |
| US-5451685-A | MANUFACTURING PHARMACEUTICALS | AMERICAN CYANAMID COMPANY (US) | 1995-09-19 | — | — | US | disclosed |
| US-5356885-A | Cholinergic agents; administering for treatment of diseases of the central nervous system | AMERICAN CYANAMID COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| EP-0510333-A1 | Substituted oxotremorine derivatives | AMERICAN CYANAMID COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |