Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847876 | 0.85 | AGTR1 (0.42) | AGTR1ALDH1A1 | |
| SCHEMBL8847590 | 0.83 | AGTR1 (0.41) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8847979 | 0.82 | AGTR1 (0.58) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8847999 | 0.81 | AGTR1 (0.51) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8848065 | 0.81 | AGTR1 (0.42) | AGTR1AGTR2WDR5ALDH1A1LMNA | |
| SCHEMBL9413559 | 0.80 | AGTR1 (0.48) | AGTR1AGTR2WDR5ALDH1A1 | |
| SCHEMBL8873288 | 0.79 | AGTR1 (0.48) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8847859 | 0.78 | AGTR1 (0.41) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL9413563 | 0.77 | AGTR1 (0.43) | AGTR1AGTR2WDR5ALDH1A1 | |
| SCHEMBL8847462 | 0.75 | AGTR1 (0.48) | AGTR1AGTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0581166-A1 | Benzimidazoles, process for their preparation and their use as angiotensin-II antagonists | Dr. Karl Thomae GmbH (DE) | 1994-02-02 | — | — | EP | disclosed |