Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 18/20 | 0.40 |
| ▸ | INSR | P06213 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885129 | 1.00 | EGFR (0.41) | EGFRALKINSRKCNH2PTK2 | |
| SCHEMBL2914305 | 0.93 | EGFR (0.43) | EGFRALKINSRKCNH2MET | |
| SCHEMBL2911541 | 0.88 | EGFR (0.43) | EGFRALKINSRMETAXL | |
| SCHEMBL2911743 | 0.82 | ALK (0.45) | EGFRALKINSRKCNH2PTK2 | |
| SCHEMBL885064 | 0.82 | ALK (0.47) | EGFRALKINSRKCNH2AXL | |
| SCHEMBL2061621 | 0.80 | ALK (0.61) | EGFRALKINSRKCNH2PTK2 | |
| SCHEMBL2061616 | 0.80 | ALK (0.61) | EGFRALKINSRKCNH2PTK2 | |
| SCHEMBL2061891 | 0.80 | ALK (0.61) | EGFRALKINSRKCNH2PTK2 | |
| SCHEMBL16571127 | 0.79 | ALK (0.46) | ALKINSRKCNH2AXL | |
| SCHEMBL16571138 | 0.79 | ALK (0.46) | ALKINSRKCNH2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |