Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 17/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911541 | 0.94 | EGFR (0.43) | EGFRALKINSRMETCDK7 | |
| SCHEMBL884841 | 0.93 | EGFR (0.41) | EGFRALKINSRKCNH2MET | |
| SCHEMBL885129 | 0.93 | EGFR (0.41) | EGFRALKINSRKCNH2MET | |
| SCHEMBL2911743 | 0.86 | ALK (0.45) | EGFRALKINSRKCNH2MET | |
| SCHEMBL884893 | 0.83 | ALK (0.60) | EGFRALK | |
| SCHEMBL2061330 | 0.80 | ALK (0.57) | EGFRALKINSRKCNH2 | |
| SCHEMBL884786 | 0.77 | EGFR (0.57) | EGFRALK | |
| SCHEMBL885042 | 0.77 | AXL (0.46) | EGFRALKINSRKCNH2CDK7 | |
| SCHEMBL884726 | 0.77 | AXL (0.46) | EGFRALKINSRKCNH2CDK7 | |
| SCHEMBL2061621 | 0.76 | ALK (0.61) | EGFRALKINSRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |