Sugi Predict

Sugi Predict / Compounds / SCHEMBL884874

SCHEMBL884874

SCHEMBL884874

Cn1cc(-c2cccc(F)c2)cn1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FLT3 P36888 3/20 0.57
▸ WNT1 P04628 1/20 0.47
▸ MET P08581 1/20 0.47
▸ DYRK1A Q13627 3/20 0.47
▸ CLK2 P49760 2/20 0.46
▸ CLK1 P49759 1/20 0.46
▸ HIPK1 Q86Z02 1/20 0.46
▸ DYRK2 Q92630 1/20 0.46
▸ HIPK2 Q9H2X6 1/20 0.46
▸ HIPK3 Q9H422 1/20 0.46
▸ CLK4 Q9HAZ1 1/20 0.46
▸ DYRK1B Q9Y463 1/20 0.46
▸ ALK Q9UM73 1/20 0.46
▸ IRAK4 Q9NWZ3 2/20 0.45
▸ CLK3 P49761 1/20 0.45
▸ IRAK1 P51617 3/20 0.45
▸ AURKB Q96GD4 2/20 0.45
▸ AURKA O14965 1/20 0.45
▸ KIT P10721 1/20 0.45
▸ PDK2 Q15119 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL18398436 0.98 FLT3 (0.56) FLT3WNT1METDYRK1ACLK2
SCHEMBL18259536 0.81 ERN1 (0.51) FLT3METDYRK1AALKAURKB
SCHEMBL19259764 0.80 DYRK1A (0.48) FLT3DYRK1ACLK2CLK1HIPK1
SCHEMBL12688 0.80 TEK (0.58) METDYRK1ACLK2CLK1HIPK1
SCHEMBL15416640 0.79 IRAK1 (0.59) IRAK4IRAK1
Ammonia Solution, Strong SCHEMBL28862497 0.79 TEK (0.56) METDYRK1ACLK2CLK1HIPK1
SCHEMBL8376983 0.79 KCNH2 (0.58) METDYRK1ACLK2CLK1HIPK1
SCHEMBL30269944 0.79 AURKB (0.54) METDYRK1ACLK2CLK1HIPK1
SCHEMBL22445210 0.79 FYN (0.60) DYRK1ACLK2CLK1HIPK1DYRK2
SCHEMBL19662770 0.79 DYRK1A (0.47) DYRK1ACLK2CLK1HIPK1DYRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3943490-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS Mission Therapeutics Limited (GB) 2022-01-26 — — EP disclosed
US-11066365-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors MISSION THERAPEUTICS LIMITED (GB) 2021-07-20 — — US disclosed
EP-3277677-B9 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS MISSION THERAPEUTICS LTD (GB) 2021-07-14 — — EP disclosed
US-11053198-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors MISSION THERAPEUTICS LIMITED (GB) 2021-07-06 — — US disclosed
EP-3842427-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS Mission Therapeutics Limited (GB) 2021-06-30 — — EP disclosed
EP-3277677-B1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS MISSION THERAPEUTICS LTD (GB) 2021-02-24 — — EP disclosed
US-10689345-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors MISSION THERAPEUTICS LIMITED (GB) 2020-06-23 — — US disclosed
US-20200181086-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS MISSION THERAPEUTICS LIMITED (GB) 2020-06-11 — — US disclosed
US-20190322624-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS MISSION THERAPEUTICS LIMITED (GB) 2019-10-24 — — US disclosed
US-20190284138-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS MISSION THERAPEUTICS LIMITED (GB) 2019-09-19 — — US disclosed
US-20190270708-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS MISSION THERAPEUTICS LIMITED (GB) 2019-09-05 — — US disclosed
US-10343992-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors Missions Therapeutics Limited (GB) 2019-07-09 — — US disclosed
US-20180086708-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS MISSION THERAPEUTICS LIMITED (GB) 2018-03-29 — — US disclosed
CN-107531690-A The amines of 4,5,6,7 tetrahydrochysene 1H pyrazolos [4,3 c] pyridine 3 as CBP and/or EP300 inhibitor 基因泰克公司 2018-01-02 — — CN disclosed
WO-2017020428-A1 NOVEL COMPOUNDS FOR USE AS JAK INHIBITORS 南昌弘益科技有限公司 2017-02-09 — — WO disclosed
EP-2429993-B1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BOEHRINGER INGELHEIM INT (DE) 2015-01-21 — — EP disclosed
WO-2010130034-A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-11-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11066365-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors USP30, USP20, USP10 FLT3 2125/4885WNT1 3681/4885MET 3669/4885
US-10343992-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors USP30, USP20, USP10 FLT3 2256/4885WNT1 3384/4885MET 3738/4885
US-11053198-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors USP30, USP20, USP10 FLT3 2256/4885WNT1 3384/4885MET 3738/4885
US-20200181086-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS USP30, USP20, USP10 FLT3 2170/4885WNT1 3287/4885MET 3654/4885
US-20190284138-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS USP30, USP20, USP10 FLT3 2125/4885WNT1 3681/4885MET 3669/4885
US-20180086708-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS USP30, USP20, USP10 FLT3 2256/4885WNT1 3384/4885MET 3738/4885
US-20190322624-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS USP30, USP20, USP10 FLT3 2256/4885WNT1 3384/4885MET 3738/4885
US-10689345-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors USP30, USP20, USP10 FLT3 2256/4885WNT1 3384/4885MET 3738/4885
US-20190270708-A1 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS USP30, USP20, USP10 FLT3 2256/4885WNT1 3384/4885MET 3738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.