SCHEMBL8848745

SCHEMBL8848745

COC(=O)c1ccccc1S(=O)(=O)N(C(N)=O)c1nc(C)nc(OC)n1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA5A P35218 1/20 0.46
CA9 Q16790 1/20 0.46
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
SLC40A1 Q9NP59 1/20 0.38
HSD17B10 Q99714 2/20 0.36
KDM4E B2RXH2 1/20 0.36
NPC1 O15118 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
ALDH1A1 P00352 2/20 0.35
CFTR P13569 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
BRD4 O60885 1/20 0.35
F2 P00734 1/20 0.34
PRSS1 P07477 1/20 0.34
PRSS2 P07478 1/20 0.34
PRSS3 P35030 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4284694 0.90 F2 (0.42) CA1CA2CA5ACA9KMT2A
SCHEMBL5458880 0.88 CA1 (0.42) CA1CA2CA5ACA9KMT2A
SCHEMBL29080891 0.85 CA1 (0.33) CA1CA2CA5ACA9KMT2A
SCHEMBL9587373 0.84 CA1 (0.48) CA1CA2CA5ACA9KMT2A
SCHEMBL10914176 0.84 MEN1 (0.56) KMT2AMEN1KDM4E
SCHEMBL6054812 0.84 CA1 (0.50) CA1CA2CA5ACA9KMT2A
SCHEMBL10390488 0.83 CA1 (0.38) CA1CA2CA5ACA9KMT2A
SCHEMBL9478884 0.83 TSHR (0.39) CA1CA2CA5ACA9KMT2A
SCHEMBL11182357 0.82 CA1 (0.42) CA1CA2CA5ACA9KMT2A
SCHEMBL7793855 0.82 EDNRA (0.41) KMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5231071-A Heterocyclic phenoxy-2-propionates HOECHST AKTIENGESELLSCHAFT (DE) 1993-07-27 US claimed
EP-0298901-B1 HERBICIDAL AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1992-01-15 EP claimed
US-9072298-B2 Synergistic herbicidal composition ROTAM AGROCHEM INTRNATIONAL COMPANY LIMITED (CN) 2015-07-07 US disclosed
US-20150126369-A1 SYNERGISTIC HERBICIDAL COMPOSITION ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (CN) 2015-05-07 US disclosed
EP-0512737-B1 Herbicidal compositions with increased crop safety DOWELANCO (US) 1997-04-16 EP disclosed
EP-0512739-B1 Herbicidal compositions with reduced phytotoxicity DOWELANCO (US) 1996-11-06 EP disclosed
US-5382564-A Synergistic mixture of benzoxazole compound and sulfonylurea HOECHST AKTIENGESELLSCHAFT (DE) 1995-01-17 US disclosed
US-5342822-A Phenoxy benzoazole derivative with amino carbonyl-amionosulfonyl thiophene carboxylate derivative HOECHST AKTIENGESELLSCHAFT (DE) 1994-08-30 US disclosed
US-5236887-A HERBICIDAL HETEROCYCLIC SULFONYLUREA COMPOSITIONS SAFENED BY HERBICIDAL ACIDS SUCH AS 2,4-D BELOW A PH OF 5 DOWELANCO (US) 1993-08-17 US disclosed
US-5231071-A Heterocyclic phenoxy-2-propionates HOECHST AKTIENGESELLSCHAFT (DE) 1993-07-27 US disclosed
EP-0512737-A1 Herbicidal compositions with increased crop safety DOWELANCO (US) 1992-11-11 EP disclosed
EP-0512739-A1 Herbicidal compositions with reduced phytotoxicity DOWELANCO (US) 1992-11-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150126369-A1 SYNERGISTIC HERBICIDAL COMPOSITION DDT, SETD1B, CTH CA1 2175/4885CA2 1769/4885CA5A 4041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.