Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 6/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.45 |
| ▸ | INSR | P06213 | 6/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884726 | 0.90 | AXL (0.46) | AXLALKINSRIGF1RAURKA | |
| SCHEMBL885064 | 0.82 | ALK (0.47) | AXLALKINSRIGF1RAURKA | |
| SCHEMBL16571127 | 0.81 | ALK (0.46) | AXLALKINSRIGF1RAURKA | |
| SCHEMBL16571138 | 0.81 | ALK (0.46) | AXLALKINSRIGF1RAURKA | |
| SCHEMBL2061704 | 0.79 | ALK (0.62) | AXLALKINSRIGF1RAURKA | |
| SCHEMBL16571264 | 0.79 | ALK (0.44) | AXLALKINSRIGF1RAURKA | |
| SCHEMBL16571402 | 0.79 | ALK (0.45) | AXLALKINSRIGF1RKCNH2 | |
| SCHEMBL2911745 | 0.77 | ALK (0.54) | AXLALKINSRIGF1RAURKA | |
| SCHEMBL2910791 | 0.77 | ALK (0.54) | AXLALKINSRIGF1RAURKA | |
| SCHEMBL2914305 | 0.77 | EGFR (0.43) | ALKINSRKCNH2CDK7CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | claimed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |