SCHEMBL8850869

SCHEMBL8850869

COC(=O)CCCNCc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.58
HDAC1 Q13547 2/20 0.58
HDAC2 Q92769 2/20 0.58
HDAC8 Q9BY41 2/20 0.58
NCOR2 Q9Y618 2/20 0.58
MAOA P21397 1/20 0.56
CHRM2 P08172 1/20 0.55
LMNA P02545 2/20 0.54
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
ATM Q13315 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
SIGMAR1 Q99720 3/20 0.51
KDM4E B2RXH2 2/20 0.50
CA12 O43570 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
CCR6 P51684 1/20 0.50
PAX8 Q06710 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28493003 0.98 HDAC3 (0.56) HDAC3HDAC1HDAC2HDAC8NCOR2
SCHEMBL19438874 0.95 HDAC3 (0.65) HDAC3HDAC1HDAC2HDAC8NCOR2
SCHEMBL16730575 0.94 HDAC3 (0.66) HDAC3HDAC1HDAC2HDAC8NCOR2
SCHEMBL13903744 0.94 HDAC3 (0.66) HDAC3HDAC1HDAC2HDAC8NCOR2
SCHEMBL537549 0.90 LTA4H (0.58) HDAC3HDAC1HDAC2HDAC8NCOR2
Water SCHEMBL28846002 0.88 LTA4H (0.57) HDAC3HDAC1HDAC2HDAC8NCOR2
SCHEMBL8851568 0.86 LTA4H (0.63) HDAC3HDAC1HDAC2HDAC8NCOR2
SCHEMBL28467893 0.85 CA12 (0.60) MEN1KMT2AATMSIGMAR1CA12
SCHEMBL16086431 0.84 HDAC3 (0.52) HDAC3HDAC1HDAC2HDAC8NCOR2
Hydrochloric Acid SCHEMBL28570780 0.84 LTA4H (0.62) HDAC3HDAC1HDAC2HDAC8NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1053472-C Oligonucleotides derived from the SOD family HOFFMANN LA ROCHE (CH) 2000-06-14 CN disclosed
US-5618814-A Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds DR. KARL THOMAE GMBH (DE) 1997-04-08 US disclosed
CN-1106405-A Trisubstituted pyrimido [5,4-d] pyrimidines for modulating THOMAE GMBH DR K (DE) 1995-08-09 CN disclosed